Numerical Simulation of a Lab-on-Chip for Dielectrophoretic Separation of Circulating Tumor Cells.

ABSTRACT: Circulating tumor cells (CTCs) are cancer cells detached from tumors that enter the bloodstream with the rest of the blood cells before settling on remote organs and growing. CTCs play a major role as a target for cancer diagnosis. This study aims to propose and simulate a lab-on-chip (LOC) design that separates CTCs from white blood cells (WBCs) and blood platelets (PLTs) using low-voltage dielectrophoretic separation with high efficiency. The proposed design include two stages a passive and an active one cascaded in a compact package. Numerical simulations are performed on the COMSOL Multiphysics^® software package to optimize the geometric parameters of the LOC, such as the width and length of the microchannel and the number of electrodes and their arrangements. Moreover, the

SUBMITTER: Alkhaiyat AM 

PROVIDER: S-EPMC10534381 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature