Liquid-Liquid Phase Separation and Protective Protein Aggregates in Bacteria.

ABSTRACT: Liquid-liquid phase separation (LLPS) and the formation of membraneless organelles (MLOs) contribute to the spatiotemporal organization of various physiological processes in the cell. These phenomena have been studied and characterized mainly in eukaryotic cells. However, increasing evidence indicates that LLPS-driven protein condensation may also occur in prokaryotes. Recent studies indicate that aggregates formed during proteotoxic stresses may also play the role of MLOs and increase the fitness of bacteria under stress. The beneficial effect of aggregates may result from the sequestration and protection of proteins against irreversible inactivation or degradation, activation of the protein quality control system and induction of dormancy. The most common stress that bacteria encounter i

SUBMITTER: Kuczynska-Wisnik D 

PROVIDER: S-EPMC10534466 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature