Negative Influence of Aging on Differentiation and Proliferation of CD8⁺ T-Cells in Dogs.

ABSTRACT: Immunosenescence is an age-related change in the immune system characterized by a reduction in naïve T-cells and an impaired proliferative capacity of CD8⁺ T-cells in older individuals. Recent research revealed the crucial impact of immunosenescence on the development and control of cancer, and aging is one of the causes that diminish the therapeutic efficacy of cancer immunotherapies targeting CD8⁺ T-cell activation. Despite dog cancer being defined as an age-related disease, there are few fundamental understandings regarding the relationship between aging and the canine immune system. Therefore, we aimed to elucidate the characteristics of immunosenescence in dogs and analyzed the effects of aging on the differentiation status and proliferation of canine CD8^+</

SUBMITTER: Yamauchi A 

PROVIDER: S-EPMC10534501 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature