Urine Peptidome Analysis Identifies Common and Stage-Specific Markers in Early Versus Advanced CKD.

ABSTRACT: Given the pathophysiological continuum of chronic kidney disease (CKD), different molecular determinants affecting progression may be associated with distinct disease phases; thus, identification of these players are crucial for guiding therapeutic decisions, ideally in a non-invasive, repeatable setting. Analyzing the urinary peptidome has been proven an efficient method for biomarker determination in CKD, among other diseases. In this work, after applying several selection criteria, urine samples from 317 early (stage 2) and advanced (stage 3b-5) CKD patients were analyzed using capillary electrophoresis coupled to mass spectrometry (CE-MS). The entire two groups were initially compared to highlight the respective pathophysiology between initial and late disease phases. Subsequently, slo

SUBMITTER: Hobson S 

PROVIDER: S-EPMC10534506 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature