Vitamin D and Its Metabolites Status before and during Chemotherapy in Caucasian Breast Cancer Patients.

ABSTRACT:

Background

The predictive role of vitamin D (VD) in breast cancer (BC) patients' survival is still being investigated. This paper aims to evaluate the changes in VD metabolites during chemotherapy (CTH) and the predictive role of VD status in Caucasian BC patients treated with CTH.

Methods

Vitamin D and its metabolites were assessed with reference LC-MS/MS methodology in 98 consecutive BC patients starting CHT, after 3 and 6 months, and compared to the control group.

Results

The frequency of VD deficiency in BC patients was greater than in the control group (56.1% vs. 37.2%). After 6 months of CTH, the number of VD-deficient BC patients slightly increased to 60%. The concentrations of VD active forms [25(OH)D₂, 25(OH)D₃], and catabolites [24,25(O

SUBMITTER: Kimsa-Furdzik M 

PROVIDER: S-EPMC10534610 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature