Fabrication of PEG-PLGA Microparticles with Tunable Sizes for Controlled Drug Release Application.

ABSTRACT: Polymeric microparticles of polyethyleneglycol-polylactic acid-co-glycolic acid (PEG-PLGA) are widely used as drug carriers for a variety of applications due to their unique characteristics. Although existing techniques for producing polymeric drug carriers offer the possibility of achieving greater production yield across a wide range of sizes, these methods are improbable to precisely tune particle size while upholding uniformity of particle size and morphology, ensuring consistent production yield, maintaining batch-to-batch reproducibility, and improving drug loading capacity. Herein, we developed a novel scalable method for the synthesis of tunable-sized microparticles with improved monodispersity and batch-to-batch reproducibility via the coaxial flow-phase separation techniqu

SUBMITTER: Sagoe PNK 

PROVIDER: S-EPMC10534673 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature