Dataset Information

Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review.

ABSTRACT:

Background

Human respiratory syncytial virus (hRSV) is a key contributor to lower respiratory tract infections (LRTIs), affecting children aged 0-5 years and often leading to outpatient visits, emergency department utilization, and hospitalization. With the development of hRSV vaccines for mitigation, understanding the epidemiological impact of hRSV infections among 0-5-year-old pediatric outpatients in Italy is crucial.

Methods

This systematic review conducted searches on PubMed, Embase, Scopus, and the International HTA Database, yielding 20,845 English and Italian records from January 2000 to July 2022.

Results

Six eligible articles were identified following inclusion and exclusion criteria. These studies demonstrated hRSV-positivity proportions ranging from 18% to 41% in pediatric outpatients with respiratory infections. However, data comparability was hindered by diverse diagnostic approaches, data sources, sample populations, and study designs. Notably, hRSV-positivity showed temporal variability, rising from 23.8% (2001-2002) to 40.6% (2019-2020). This trend could stem from evolving epidemiological factors, heightened clinician awareness in hRSV diagnosis, or more sensitive molecular techniques.

Conclusion

As the first review of its kind, this study underscores the need for more comprehensive data to inform effective preventive strategies against hRSV-related burdens in pediatric outpatients.

SUBMITTER: Boccalini S

PROVIDER: S-EPMC10534716 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review.

Boccalini Sara S Bonito Benedetta B Salvati Cristina C Del Riccio Marco M Stancanelli Enrica E Bruschi Mario M Ionita Giulia G Iamarino Johanna J Bentivegna Davide D Buscemi Primo P Ciardi Giulia G Cosma Claudia C Stacchini Lorenzo L Conticello Cristiana C Bega Manjola M Schirripa Annamaria A Paoli Sonia S Bertizzolo Lorenzo L Parisi Salvatore S Trippi Francesca F Bonanni Paolo P Bechini Angela A

Vaccines 20230914 9

<h4>Background</h4>Human respiratory syncytial virus (hRSV) is a key contributor to lower respiratory tract infections (LRTIs), affecting children aged 0-5 years and often leading to outpatient visits, emergency department utilization, and hospitalization. With the development of hRSV vaccines for mitigation, understanding the epidemiological impact of hRSV infections among 0-5-year-old pediatric outpatients in Italy is crucial.<h4>Methods</h4>This systematic review conducted searches on PubMed, ...[more]

PMID: 37766160

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Dataset Information

Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review.

Background

Methods

Results

Conclusion

Publications

Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review.

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