Estimation of the Cadmium Nephrotoxicity Threshold from Loss of Glomerular Filtration Rate and Albuminuria.

ABSTRACT: Cadmium (Cd) is a pervasive, toxic environmental pollutant that preferentially accumulates in the tubular epithelium of the kidney. Current evidence suggests that the cumulative burden of Cd here leads to the progressive loss of the glomerular filtration rate (GFR). In this study, we have quantified changes in estimated GFR (eGFR) and albumin excretion (E_alb) according to the levels of blood Cd ([Cd]_b) and excretion of Cd (E_Cd) after adjustment for confounders. E_Cd and E_alb were normalized to creatinine clearance (C_cr) as E_Cd/C_cr and E_alb/C_cr. Among 482 residents of Cd-polluted and non-polluted regions of Thailand, 8.1% had low eGFR and 16.9% had albuminuria (E_alb/C

SUBMITTER: Satarug S 

PROVIDER: S-EPMC10534899 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature