Synthesis of Novel Heterocyclic Ferrocenyl Chalcones and Their Biological Evaluation.

ABSTRACT: Breast cancer is currently the most commonly diagnosed cancer, with 287,850 new cases estimated for 2022 as reported by the American Cancer Society. Therefore, finding an effective treatment for this disease is imperative. Chalcones are α,β-unsaturated systems found in nature. These compounds have shown a wide array of biological activities, making them popular synthetic targets. Chalcones consist of two aromatic substituents connected by an enone bridge; this arrangement allows for a large number of derivatives. Given the biological relevance of these compounds, novel ferrocene-heterocycle-containing chalcones were synthesized and characterized based on a hybrid drug design approach. These heterocycles included thiophene, pyrimidine, thiazolyl, and indole groups. Fourteen novel heterocycl

SUBMITTER: Alsina-Sanchez AM 

PROVIDER: S-EPMC10534901 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature