Antidepressant Use and Risk of Manic Episodes in Children and Adolescents With Unipolar Depression.

ABSTRACT:

Importance

Antidepressants are increasingly prescribed to pediatric patients with unipolar depression, but little is known about the risk of treatment-emergent mania. Previous research suggests pediatric patients may be particularly vulnerable to this adverse outcome.

Objective

To estimate whether pediatric patients treated with antidepressants have an increased incidence of mania/hypomania compared with patients not treated with antidepressants and to identify patient characteristics associated with the risk of mania/hypomania.

Design, setting, and participants

In a cohort study applying the target trial emulation framework, nationwide inpatient and outpatient care in Sweden from July 1, 2006, to December 31, 2019, was evaluated. Follow-up was conducted for 12 and 52

SUBMITTER: Virtanen S 

PROVIDER: S-EPMC10534997 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature