Calcium Homeostasis and Psychiatric Disorders: A Mendelian Randomization Study.

ABSTRACT: Observational studies have investigated the impact of calcium homeostasis on psychiatric disorders; however, the causality of associations is yet to be established. Bidirectional Mendelian randomization (MR) analysis of calcium homeostasis hormones was conducted on nine psychiatric disorders. Calcium, serum 25-hydroxyvitamin D levels (25OHD), parathyroid hormone, and fibroblast growth factor 23 are the major calcium homeostasis hormones. The causality was evaluated by the inverse variance weighted method (IVW) and the MR Steiger test, while Cochran's Q test, the MR-Egger intercept test, funnel plot, and the leave-one-out method were used for sensitivity analyses. Bonferroni correction was used to determine the causative association features (p < 6.94 × 10^-4). Schizophreni

SUBMITTER: Jiang M 

PROVIDER: S-EPMC10535008 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature