Transcriptomic Profiling after In Vitro Δ⁸-THC Exposure Shows Cytoskeletal Remodeling in Trauma-Injured NSC-34 Cell Line.

ABSTRACT: Neuronal cell death is a physiological process that, when uncontrollable, leads to neurodegenerative disorders like spinal cord injury (SCI). SCI represents one of the major causes of trauma and disabilities worldwide for which no effective pharmacological intervention exists. Herein, we observed the beneficial effects of Δ⁸-Tetrahydrocannabinol (Δ⁸-THC) during neuronal cell death recovery. We cultured NSC-34 motoneuron cell line performing three different experiments. A traumatic scratch injury was caused in two experiments. One of the scratched was pretreated with Δ⁸-THC to observe the role of the cannabinoid following the trauma. An experimental control group was neither scratched nor pretreated. All the experiments underwent RNA-seq analysis. The effect

SUBMITTER: Chiricosta L 

PROVIDER: S-EPMC10535185 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature