Development of a Generic PBK Model for Human Biomonitoring with an Application to Deoxynivalenol.

ABSTRACT: Toxicokinetic modelling provides a powerful tool in relating internal human exposure (i.e., assessed through urinary biomarker levels) to external exposure. Chemical specific toxicokinetic models are available; however, this specificity prevents their application to similar contaminants or to other routes of exposure. For this reason, we investigated whether a generic physiological-based kinetic (PBK) model might be a suitable alternative for a biokinetic model of deoxynivalenol (DON). IndusChemFate (ICF) was selected as a generic PBK model, which could be fit for purpose. Being suited for simulating multiple routes of exposure, ICF has particularly been used to relate the inhalation and dermal exposure of industrial chemicals to their urinary excretion. For the first time, the ICF model w

SUBMITTER: Notenboom S 

PROVIDER: S-EPMC10535232 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature