Beauvericin Immunotoxicity Prevention by Gentiana lutea L. Flower In Vitro.

ABSTRACT: Beauvericin (BEA) is an emerging mycotoxin produced by some species of Fusarium genera that widely contaminates food and feed. Gentiana lutea is a protected medicinal plant known for its antioxidant and anti-inflammatory properties, which are attributed to its rich content of bioactive compounds. In order to evaluate the beneficial effects of G. lutea flower against BEA cytotoxicity, the aim of this study is to evaluate changes in protein expression after Jurkat cell exposure through a proteomics approach. To carry out the experiment, cells were exposed to intestinally digested G. lutea flower alone or in combination with the BEA standard (100 nM) over 7 days. Differentially expressed proteins were statistically evaluated (p < 0.05), revealing a total of 172 pro

SUBMITTER: Di Matteo G 

PROVIDER: S-EPMC10535299 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature