Enhanced IL-17 Producing and Maintained Cytolytic Effector Functions of Gut Mucosal CD161⁺CD8⁺ T Cells in SIV-Infected Rhesus Macaques.

ABSTRACT: Previous studies have indicated that the loss of CD161-expressing CD4⁺ Th17 cells is linked to the progression of chronic HIV. These cells are significantly depleted in peripheral blood and gut mucosa of HIV-infected individuals, contributing to inflammation and disruption of the gut barrier. However, the impact of HIV infection on CD161-expressing CD8⁺ T cells remain unclear. Here, we examined the functions of peripheral blood and mucosal CD161⁺CD8⁺ T cells in the macaque model of HIV infection. In contrast to the significant loss of CD161⁺CD4⁺ T cells, CD161⁺CD8⁺ T cell frequencies were maintained in blood and gut during chronic SIV infection. Furthermore, gut CD161⁺CD8⁺ T cells

SUBMITTER: Thirugnanam S 

PROVIDER: S-EPMC10535321 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature