Can Pharmaceutical Excipients Threaten the Aquatic Environment? A Risk Assessment Based on the Microtox^® Biotest.

ABSTRACT: The ecotoxicological impact of pharmaceuticals has received considerable attention, primarily focusing on active pharmaceutical ingredients (APIs) while largely neglecting the potential hazards posed by pharmaceutical excipients. Therefore, we analyzed the ecotoxicity of 16 commonly used pharmaceutical excipients, as well as 26 API-excipient and excipient-excipient mixtures utilizing the Microtox^® test. In this way, we assessed the potential risks that pharmaceutical excipients, generally considered safe, might pose to the aquatic environment. We investigated both their individual ecotoxicity and their interactions with tablet ingredients using concentration addition (CA) and independent action (IA) models to shed light on the often-overlooked ecotoxicological consequences of th

SUBMITTER: Turek M 

PROVIDER: S-EPMC10535389 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature