SARS-CoV-2-Specific CD8⁺ T-Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after Infection.

ABSTRACT: Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 enters the host by infecting nasal ciliated cells. Then, the virus can spread towards the oropharyngeal cavity and the pulmonary tissues. The antiviral adaptive immunity is promptly induced in response to the virus's detection, with virus-specific T-lymphocytes appearing before antiviral antibodies. Both the breadth and potency of antiviral CD8⁺ T-cell immunity have a key role in containing viral spread and disease severity. Current anti-SARS-CoV-2 vaccines do not impede the virus's replication in the upper respiratory tract, and there is consensus on the fact that the best potency of the antiviral immune response in both blood and the upper respiratory tract can be reached upon infection in vaccinees (i.e., breakthrough

SUBMITTER: Ferrantelli F 

PROVIDER: S-EPMC10535545 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature