Comparison of Policosanols via Incorporation into Reconstituted High-Density Lipoproteins: Cuban Policosanol (Raydel^®) Exerts the Highest Antioxidant, Anti-Glycation, and Anti-Inflammatory Activity.

ABSTRACT: Reconstituted high-density lipoproteins (rHDL) containing each policosanol from Cuba (Raydel^®), China (Shaanxi Pioneer), and the United States (Lesstanol^®) were synthesized to compare the physiological properties of policosanol depending on sources and origin countries. After synthesis with apolipoproteinA-I (apoA-I) into rHDL, all policosanols bound well with phospholipid and apoA-I to form discoidal rHDL. An rHDL containing Cuban policosanol (rHDL-1) showed the largest rHDL particle size of around 83 ± 3 nm, while rHDL containing Chinese policosanol (rHDL-2) or American policosanol (rHDL-3) showed smaller particles around 63 ± 3 nm and 60 ± 2 nm in diameter, respectively. The rHDL-1 showed the strongest anti-glycation activity to protect the apoA-I degradation of HD

SUBMITTER: Cho KH 

PROVIDER: S-EPMC10535602 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature