Hot Melt Extrusion for Improving the Physicochemical Properties of Polydatin Derived from Polygoni cuspidati Extract; A Solution Recommended for Buccal Applications.

ABSTRACT: Three different types of solid dispersions based on polyvinyl polymers and related copolymers (Kollidon^® VA64, Soluplus^® and Kollicoat IR^®) comprising polydatin-rich Polygoni cuspidati extract were prepared by hot melt extrusion. The systems were characterized using X-ray powder diffraction, infrared spectroscopy as well as by polydatin release and in vitro permeability. Mucoadhesive tablets were prepared from the extrudates based on Kollidon^® VA64 and Soluplus^® to obtain a suitable pharmaceutical form, where (hydroxypropyl)methyl cellulose was added as a mucoadhesive agent. The tablets were evaluated in terms of the kinetics of polydatin release as well as their mucoadhesive properties. The best tabletability properties, polyda

SUBMITTER: Paczkowska-Walendowska M 

PROVIDER: S-EPMC10535885 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature