Characterization of Bovine Intraepithelial T Lymphocytes in the Gut.

ABSTRACT: Intraepithelial T lymphocytes (T-IELs), which constitute over 50% of the total T lymphocytes in the animal, patrol the mucosal epithelial lining to defend against pathogen invasion while maintaining gut homeostasis. In addition to expressing T cell markers such as CD4 and CD8, T-IELs display T cell receptors (TCR), including either TCRαβ or TCRγδ. Both humans and mice share similar T-IEL subsets: TCRγδ⁺, TCRαβ⁺CD8αα⁺, TCRαβ⁺CD4⁺, and TCRαβ⁺CD8αβ⁺. Among these subsets, human T-IELs are predominantly TCRαβ⁺ (over 80%), whereas those in mice are mostly TCRγδ⁺ (~60%). Of note, the majority of the TCRγδ⁺ subset expresses CD8αα in both species. Although T-IELs have been extensively studi

SUBMITTER: Hada A 

PROVIDER: S-EPMC10535955 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature