Electrooxidative Hofmann Rearrangement of Phthalimides to Access Anthranilate Derivatives.

ABSTRACT: A simple and efficient electrooxidative Hofmann rearrangement reaction of phthalimides was developed. Anthranilate derivatives were synthesized in moderate to good yields under green and mild conditions using phthalimides as a rearrangement precursor. This approach not only provides a strategy for synthesizing anthranilates and deuterated anthranilate derivatives with high deuteration efficiency but also realizes efficient conversion at the gram scale. A possible reaction mechanism is proposed.

SUBMITTER: Wang J 

PROVIDER: S-EPMC10536198 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature