Systemic juvenile idiopathic arthritis: The Great Ormond Street Hospital experience (2005-2021).

ABSTRACT: Systemic juvenile idiopathic arthritis (sJIA) is a complex, systemic inflammatory disorder driven by both innate and adaptive immunity. Improved understanding of sJIA pathophysiology has led to recent therapeutic advances including a growing evidence base for the earlier use of IL-1 or IL-6 blockade as first-line treatment. We conducted a retrospective case notes review of patients diagnosed with sJIA over a 16-year period (October 2005-October 2021) at Great Ormond Street Hospital for Children. We describe the clinical presentation, therapeutic interventions, complications, and remission rates at different timepoints over the disease course. We examined our data, which spanned a period of changing therapeutic landscape, to try and identify potential therapeutic signals in patients who rec

SUBMITTER: Foley CM 

PROVIDER: S-EPMC10536248 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature