Malaria Vaccines: From the Past towards the mRNA Vaccine Era.

ABSTRACT: Plasmodium spp. is the etiological agent of malaria, a life-threatening parasitic disease transmitted by infected mosquitoes. Malaria remains a major global health challenge, particularly in endemic regions. Over the years, various vaccine candidates targeting different stages of Plasmodium parasite life-cycle have been explored, including subunit vaccines, vectored vaccines, and whole organism vaccines with Mosquirix, a vaccine based on a recombinant protein, as the only currently approved vaccine for Plasmodium falciparum malaria. Despite the aforementioned notable progress, challenges such as antigenic diversity, limited efficacy, resistant parasites escaping protective immunity and the need for multiple doses have hindered the development of a highly efficacious ma

SUBMITTER: Tsoumani ME 

PROVIDER: S-EPMC10536368 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature