Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives.

ABSTRACT: Phosphodiesterase 5 (PDE5) inhibitors presented themselves as important players in the nitric oxide/cGMP pathway, thus exerting a profound impact on various physiological and pathological processes. Beyond their well-known efficacy in treating male erectile dysfunction (ED) and pulmonary arterial hypertension (PAH), a plethora of studies have unveiled their significance in the treatment of a myriad of other diseases, including cognitive functions, heart failure, multiple drug resistance in cancer therapy, immune diseases, systemic sclerosis and others. This comprehensive review aims to provide an updated assessment of the crucial role played by PDE5 inhibitors (PDE5-Is) as disease-modifying agents taking their limiting side effects into consideration. From a medicinal chemistry and drug di

SUBMITTER: ElHady AK 

PROVIDER: S-EPMC10536424 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature