Lymphoma in Border Collies: Genome-Wide Association and Pedigree Analysis.

ABSTRACT: There has been considerable interest in studying cancer in dogs and its potential as a model system for humans. One area of research has been the search for genetic risk variants in canine lymphoma, which is amongst the most common canine cancers. Previous studies have focused on a limited number of breeds, but none have included Border Collies. The aims of this study were to identify relationships between Border Collie lymphoma cases through an extensive pedigree investigation and to utilise relationship information to conduct genome-wide association study (GWAS) analyses to identify risk regions associated with lymphoma. The expanded pedigree analysis included 83,000 Border Collies, with 71 identified lymphoma cases. The analysis identified affected close relatives, and a common ancestor

SUBMITTER: Soh PXY 

PROVIDER: S-EPMC10536503 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature