Castration promotes the browning of the prostate tumor microenvironment.

ABSTRACT:

Background

Adipose tissue has gained attention due to its potential paracrine role. Periprostatic adipose tissue surrounds the prostate and the prostatic urethra, and it is an essential player in prostate cancer progression. Since obesity is directly related to human tumor progression, and adipose tissue depots are one of the significant components of the tumor microenvironment, the molecular mediators of the communication between adipocytes and epithelial cells are in the spotlight. Although periprostatic white adipose tissue contributes to prostate cancer progression, brown adipose tissue (BAT), which has beneficial effects in metabolic pathologies, has been scarcely investigated concerning cancer progression. Given that adipose tissue is a target of androgen signaling, the actua

SUBMITTER: Alvarez-Artime A 

PROVIDER: S-EPMC10536697 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature