In Vitro, Oral Acute, and Repeated 28-Day Oral Dose Toxicity of a Mixed-Valence Polyoxovanadate Cluster.

ABSTRACT: Polyoxovanadates (POV) are a subgroup of polyoxometalates (POM), which are nanosized clusters with reported biological activities. This manuscript describes the first toxicity evaluation of a mixed-valence polyoxovanadate, pentadecavanadate, (Me₄N)₆[V₁₅O₃₆Cl], abbreviated as V₁₅. Cytotoxicity experiments using peripheral blood mononuclear cells (PBMC), larvae of Artemia salina Leach, and in vivo oral acute and repeated 28-day doses in mice was carried out. The LC₅₀ values in PBMC cells and A. salina were 17.5 ± 5.8 μmol L^-1, and 17.9 µg L^-1, respectively, which indicates high cytotoxic activity. The toxicity in mice was not observed upon acute exposure in a single dose, however, the V

SUBMITTER: Barbosa MM 

PROVIDER: S-EPMC10536805 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature