Therapeutic Potential of Antiviral Peptides against the NS2B/NS3 Protease of Zika Virus.

ABSTRACT: The NS2B/NS3 protease is highly conserved among various proteases of the Zika virus, making it an important therapeutic target for developing broad-spectrum antiviral drugs. The NS2B/NS3 protease is a crucial enzyme in the replication cycle of Zika virus and plays a significant role in viral maturation and assembly. Inhibiting the activity of this protease can potentially prevent viral replication, making it an attractive target for developing therapies against Zika virus infection. This work screens 429 antiviral peptides in comparison with substrate peptide against the NS2B/NS3 of Zika virus using molecular docking and molecular dynamics (MD) simulation. Based on the docking screening, MD simulation conducted for the best four peptides including AVP0239, AVP0642, AVP0660, and AVP2044, co

SUBMITTER: Hossain MS 

PROVIDER: S-EPMC10536883 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature