Preliminary Study on the Effect and Molecular Mechanism of Tetrandrine in Alleviating Pulmonary Inflammation and Fibrosis Induced by Silicon Dioxide.

ABSTRACT: This study aims to explore the molecular mechanism of tetrandrine (Tet) in alleviating pulmonary inflammation and fibrosis induced by silica (SiO₂) from the perspective of autophagy. C57BL/6J mice were selected as experimental animals, and SiO₂ was exposed by intranasal instillation. Tet was intervened by oral gavage. The mice were euthanized on the 7th and 42nd day of SiO₂ exposure, and lung tissues were collected for histopathological, molecular biological, immunological, and transmission electron microscopy analysis. The results showed that SiO₂ exposure could lead to significant lung inflammation and fibrosis, while Tet could significantly reduce SiO₂ exposure-induced lung inflammation and fibrosis. Molecular mechanism research ind

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10536946 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature