The Prognostic and Therapeutic Role of Histone Acetylation Modification in LIHC Development and Progression.

ABSTRACT: Background and Objectives: The modification of histone acetylation plays a vital role in regulating tumor occurrence and development, but the interaction between histone acetylation modulator genes and the liver hepatocellular carcinoma (LIHC) microenvironment, as well as immunotherapy, has not been investigated. Materials and Methods: Analysis of all statistical data was carried out using R software (Version 4.2.0) and the online tool Sangerbox. Comprehensive bioinformatics analysis, including signature construction and validation, functional analyses, immune and genomic features analyses, and immunotherapy prediction analyses, were performed to explore the prognostic and therapeutic role of histone acetylation modulator genes in LIHC development and progression. Results:

SUBMITTER: Gao J 

PROVIDER: S-EPMC10536947 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature