Cytotoxic effects of halophilic archaea metabolites on ovarian cancer cell lines.

ABSTRACT:

Background

Ovarian cancer is one of the most frequent and deadly gynaecological cancers, often resistant to platinum-based chemotherapy, the current standard of care. Halophilic microorganisms have been shown to produce a large variety of metabolites, some of which show toxicity to various cancer cell lines. However, none have yet been shown to be active against ovarian cancer cells. Here, we examined the effects of metabolites secreted by the halophilic archaea Halorhabdus rudnickae and Natrinema salaciae on various cancer cell lines, including ovarian cancer cell lines.

Results

¹H NMR analyses of Hrd. rudnickae and Nnm. salaciae culture supernatants contain a complex mixture of metabolites that differ between species, and even between two different strains of th

SUBMITTER: Kowalewicz-Kulbat M 

PROVIDER: S-EPMC10537157 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature