Peripheral Blood Serum NMR Metabolomics Is a Powerful Tool to Discriminate Benign and Malignant Ovarian Tumors.

ABSTRACT: Ovarian cancer is the major cause of death from gynecological cancer and the third most common gynecological malignancy worldwide. Despite a slight improvement in the overall survival of ovarian carcinoma patients in recent decades, the cure rate has not improved. This is mainly due to late diagnosis and resistance to therapy. It is therefore urgent to develop effective methods for early detection and prognosis. We hypothesized that, besides being able to distinguish serum samples of patients with ovarian cancer from those of patients with benign ovarian tumors, ¹H-NMR metabolomics analysis might be able to predict the malignant potential of tumors. For this, serum ¹H-NMR metabolomics analyses were performed, including patients with malignant, benign and borderline ov

SUBMITTER: Nunes SC 

PROVIDER: S-EPMC10537270 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature