Synthesis and Evaluation of ^99mTc-Labelled 2-Nitroimidazole Derivatives with Different Linkers for Tumour Hypoxia Imaging.

ABSTRACT: When developing novel radiopharmaceuticals, a linker moiety between the chelator and targeting vector can have a crucial influence on adjusting the affinity of the tracer and its biodistribution in organisms. To develop novel ^99mTc-labelled hypoxia imaging radiotracers, in this study, five isocyanide-containing 2-nitroimidazole derivatives with different linkers (L1, L2, L3, L4 and L5) were synthesised and radiolabelled with technetium-99m to obtain five stable ^99mTc-complexes ([^99mTc]Tc-L1, [^99mTc]Tc-L2, [^99mTc]Tc-L3, [^99mTc]Tc-L4 and [^99mTc]Tc-L5). Corresponding rhenium analogues of [^99mTc]Tc-L1 were synthesised and suggested the structures of these ^99mTc-complexes would be a monovalent cat

SUBMITTER: Ruan Q 

PROVIDER: S-EPMC10537343 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature