Critical Assessment of the Chemical Space Covered by LC-HRMS Non-Targeted Analysis.

ABSTRACT: Non-targeted analysis (NTA) has emerged as a valuable approach for the comprehensive monitoring of chemicals of emerging concern (CECs) in the exposome. The NTA approach can theoretically identify compounds with diverse physicochemical properties and sources. Even though they are generic and have a wide scope, non-targeted analysis methods have been shown to have limitations in terms of their coverage of the chemical space, as the number of identified chemicals in each sample is very low (e.g., ≤5%). Investigating the chemical space that is covered by each NTA assay is crucial for understanding the limitations and challenges associated with the workflow, from the experimental methods to the data acquisition and data processing techniques. In this review, we examined recent NTA studies publ

SUBMITTER: Hulleman T 

PROVIDER: S-EPMC10537454 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature