Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery System.

ABSTRACT: Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization in terms of shapes, sizes, or delivered drug doses, the modulation of drug release profiles is crucial to ensure the superior efficacy and safety of modern 3D-printed medications compared to those of conventional ones. Our work aims to solidify the groundwork for the preparation of 3D-printed tablets that ensure the sustained release of diclofenac sodium. Specifically, we achieved the fast release of a diclofenac sodium dose to allow for the prompt onset of its pharmacological effect, further sustaining by the slow release of another dose to maintain th

SUBMITTER: Crisan AG 

PROVIDER: S-EPMC10537489 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature