Impact of Sleeve Gastrectomy on Fecal Microbiota in Individuals with Morbid Obesity.

ABSTRACT:

Background

The intestinal microbiota plays an important role in the etiology of obesity. Sleeve gastrectomy (SG) is a frequently performed and effective therapy for morbid obesity.

Objective

To investigate the effect of sleeve gastrectomy on the fecal microbiota of individuals with morbid obesity and to examine whether shifts in microbiota composition are associated with markers of inflammation and intestinal barrier function.

Methods

Fecal and blood samples of healthy individuals (n = 27) and morbidly obese individuals pre-SG (n = 24), and at 2 months (n = 13) and 6 months post-SG (n = 9) were collected. The 16SrRNA gene was sequenced to assess microbiota composition. Fecal calprotectin, plasma inflammatory markers and intestinal permeability markers (multi-sugar tes

SUBMITTER: Tedjo DI 

PROVIDER: S-EPMC10537490 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature