Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles.

ABSTRACT:

Background

Macrophages are highly plastic innate immune cells that play key roles in host defense, tissue repair, and homeostasis maintenance. In response to divergent stimuli, macrophages rapidly alter their functions and manifest a wide polarization spectrum with two extremes: M1 or classical activation and M2 or alternative activation. Extracellular vesicles (EVs) secreted from differentially activated macrophages have been shown to have diverse functions, which are primarily attributed to their microRNA cargos. The role of protein cargos in these EVs remains largely unexplored. Therefore, in this study, we focused on the protein cargos in macrophage-derived EVs.

Results

Naïve murine bone marrow-derived macrophages were treated with lipopolysaccharide or interlukin-4 to i

SUBMITTER: Liu B 

PROVIDER: S-EPMC10537535 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature