Synthesis of α-Chloroarylacetic Acid via Electrochemical Carboxylation of α,α-Dichloroarylmethane Derivatives.

ABSTRACT: The electrocarboxylation of α,α-dichloroarylmethane derivatives in the presence of CO₂ was achieved, providing several α-chloroarylacetic acid derivatives with modest yields but high selectivity (chlorinated vs. non-chlorinated or dicarboxylic acid products). The obtained products were then involved in several chemical transformations, underlining their potential as versatile intermediates in synthetic chemistry. A mechanism was also proposed based upon a control experiment and cyclic voltammetry (CV) study.

SUBMITTER: Maret C 

PROVIDER: S-EPMC10537669 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature