Inflammasomes in Atherosclerosis-From Pathophysiology to Treatment.

ABSTRACT: Atherosclerosis, a chronic inflammatory disease characterized by arterial plaque accumulation, remains a significant global health challenge. In recent years, inflammasomes, the intracellular multiprotein complexes crucial for initiating innate immune responses, have emerged as key players in atherosclerosis pathophysiology. This review article aims to provide a comprehensive overview of the current understanding of inflammasome activation and its impact on atherosclerosis development and progression. We explore the intricate interplay between traditional cardiovascular risk factors and inflammasome activation, leading to the perpetuation of inflammatory cascades that drive plaque formation and instability. The review focuses on the molecular mechanisms underlying inflammasome activation,

SUBMITTER: Theofilis P 

PROVIDER: S-EPMC10537692 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature