One for all-human kidney Caki-1 cells are highly susceptible to infection with corona- and other respiratory viruses.

ABSTRACT: In vitro investigations of host-virus interactions are reliant on suitable cell and tissue culture models. Results are only as good as the model they are generated in. However, choosing cell models for in vitro work often depends on availability and previous use alone. Despite the vast increase in coronavirus research over the past few years, scientists are still heavily reliant on: non-human, highly heterogeneous or not fully differentiated, or naturally unsusceptible cells requiring overexpression of receptors and other accessory factors. Complex primary or stem cell models are highly representative of human tissues but are expensive and time-consuming to develop and maintain with limited suitability for high-throughput experiments.Using tissue-specific expression patterns,

SUBMITTER: Daniels A 

PROVIDER: S-EPMC10537734 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature