Non-Structural Proteins (Nsp): A Marker for Detection of Human Coronavirus Families.

ABSTRACT: SARS-CoV-2 was the cause of the global pandemic that caused a total of 14.9 million deaths during the years 2020 and 2021, according to the WHO. The virus presents a mutation rate between 10-5 and 10-3 substitutions per nucleotide site per cell infection (s/n/c). Due to this, studies aimed at knowing the evolution of this virus could help us to foresee (through the future development of new detection strategies and vaccines that prevent the infection of this virus in human hosts) that a pandemic caused by this virus will be generated again. In this research, we performed a functional annotation and identification of changes in Nsp (non-structural proteins) domains in the coronavirus genome. The comparison of the 13 selected coronavirus pangenomes demonstrated a total of 69 protein families

SUBMITTER: Tamayo-Ordonez MC 

PROVIDER: S-EPMC10537875 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature