Lymphocytic hypophysitis in dogs infected with Leishmania spp.

ABSTRACT:

Background

Morphological involvement of endocrine glands, such as the pituitary gland, remain uninvestigated in dogs with canine visceral leishmaniasis. Therefore, this study investigated the presence of amastigotes of Leishmania spp. and characterized inflammatory changes, highlighting the involvement of TCD3⁺ lymphocytes in different regions of the pituitary gland of dogs.

Methods

Samples were collected from 21 naturally infected dogs and 5 control, uninfected dogs. The different pituitary regions were analyzed in histological sections stained with hematoxylin and eosin (HE) under light microscopy. Inflammation was classified by intensity in a score from 0 to 3, absent (0), mild (1), moderate (2), and marked (3). The immunohistochemical (IHC) evaluation w

SUBMITTER: Frigerio ED 

PROVIDER: S-EPMC10537919 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature