Comparative effectiveness of pharmacological interventions for hand osteoarthritis: a systematic review and network meta-analysis of randomised trials.

ABSTRACT:

Objective

To explore the comparative effectiveness of pharmacological interventions for hand osteoarthritis (OA).

Methods

We systematically searched Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials from inception until 26 December 2021, for randomised trials of pharmacological interventions for people with hand OA. Two reviewers independently extracted study data and assessed the risk of bias. We calculated the effect sizes for pain (standardised mean differences) using Bayesian random effects models for network meta-analysis (NMA) and pairwise meta-analysis. Based on a pre-specified protocol, we prospectively registered the study at PROSPERO, CRD42021215393.

Results

We included 72 trials with 7609 participants. 65 trials (n=5957) were eligible

SUBMITTER: Dossing A 

PROVIDER: S-EPMC10537980 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature