Safety assessment of fluorescently labeled anti-EGFR Nanobodies in healthy dogs.

ABSTRACT: Introduction: Surgical resection is one of the main treatment options for several types of cancer, the desired outcome being complete removal of the primary tumor and its local metastases. Any malignant tissue that remains after surgery may lead to relapsing disease, negatively impacting the patient's quality of life and overall survival. Fluorescence imaging in surgical oncology aims to facilitate full resection of solid tumors through the visualization of malignant tissue during surgery, following the administration of a fluorescent contrast agent. An important class of targeting molecules are Nanobodies^® (Nbs), small antigen-binding fragments derived from camelid heavy chain only antibodies. When coupled with a fluorophore, Nbs can bind to a specific receptor and demar

SUBMITTER: do Valle NCH 

PROVIDER: S-EPMC10538052 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature