Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin.

ABSTRACT: In this study, multicore-like iron oxide (Fe₃O₄) and manganese ferrite (MnFe₂O₄) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures and displayed sizes of 20 ± 3 nm (Fe₃O₄) and 11 ± 2 nm (MnFe₂O₄). The Fe₃O₄ nanoparticles showed a higher saturation magnetization and heating efficiency compared with the MnFe₂O₄ nanoparticles. Functionalization with citrate and bovine serum albumin was found to improve the stability and modified surface properties. The nanoparticles were encapsulated in nanogels, and provided high drug encapsulati

SUBMITTER: Veloso SRS 

PROVIDER: S-EPMC10538132 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature