Spheroid Formation and Recovery Using Superhydrophobic Coating for Regenerative Purposes.

ABSTRACT: Cell therapies commonly pursue tissue stimulation for regenerative purposes by replacing cell numbers or supplying for functional deficiencies. To this aim, monodispersed cells are usually transplanted for incorporation by local injection. The limitations of this strategy include poor success associated with cell death, insufficient retention, or cell damage due to shear forces associated with the injection. Spheroids have recently emerged as a model that mimics an in vivo environment with more representative cell-to-cell interactions and better intercellular communication. Nevertheless, cost-effective and lab friendly fabrication and effectively performed recovery are challenges that restrict the broad application of spheroids. In this work, glass surfaces were modified with an environmen

SUBMITTER: Moran MDC 

PROVIDER: S-EPMC10538210 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature