Putting a "C₆₀ Ball" and Chain to Chlorin e6 Improves Its Cellular Uptake and Photodynamic Performances.

ABSTRACT: Chlorin e6 (Ce6) and fullerene (C₆₀) are among the most used photosensitizers (PSs) for photodynamic therapy (PDT). Through the combination of the chemical and photophysical properties of Ce6 and C₆₀, in principle, we can obtain an "ideal" photosensitizer that is able to bypass the limitations of the two molecules alone, i.e., the low cellular uptake of Ce6 and the scarce solubility and absorption in the red region of the C₆₀. Here, we synthesized and characterized a Ce6-C₆₀ dyad. The UV-Vis spectrum of the dyad showed the typical absorption bands of both fullerene and Ce6, while a quenching of Ce6 fluorescence was observed. This behavior is typical in the formation of a fullerene-antenna system and is due to the intramolecular energy, or electro

SUBMITTER: Di Sante M 

PROVIDER: S-EPMC10538216 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature