Zerumbone ameliorates the inflammatory response and organ damage in severe acute pancreatitis via the ROS/NF-κB pathway.

ABSTRACT:

Objective

The aim of the current study was to determine the mechanism by which Zerumbone (ZER) ameliorates inflammation and organ damage in a rat model of severe acute pancreatitis (SAP).

Methods

Different concentrations of ZER (10, 20 and 40 mg/kg) were administered by femoral vein puncture 30 min prior to establishment of the SAP model. Hematoxylin and eosin (H&E) staining was used to assess pathological changes in the pancreatic tissue of SAP-induced rats. The lung wet/dry (W/D) ratio was assessed and serum levels of amylase (AMY), alanine aminotransferase (ALT), creatinine (Cr), aspartate aminotransferase (AST) and phospholipase A₂ (PLA₂) were measured. Western blot analysis was used to examine changes in the expression of ROS/NF-κB pathway-associat

SUBMITTER: Zhang F 

PROVIDER: S-EPMC10538248 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature