Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2.

ABSTRACT:

Background

During hepatic ischemia-reperfusion injury, the excessive release of inflammatory cytokines can activate the intracellular signal transduction cascade to induce hepatocyte injury. Apoptosis is an important way of cell death after I/R injury. Berberine, a common quaternary ammonium alkaloid, has anti-inflammatory, anti-oxidative stress, and anti-apoptotic effects. An increasing number of studies have revealed the importance of non-coding RNAs, including microRNA, long non-coding RNAs and circular RNAs (circRNAs), as regulators of the effects of berberine.

Purpose

In this study, we investigated the mechanism of berberine against liver ischemia-reperfusion injury in vitro.

Study design and methods

In this study, hypoxia-reoxygenation (H/R)-treated L02 c

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10538280 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature