Physalis Mottle Virus-Like Nanocarriers with Expanded Internal Loading Capacity.

ABSTRACT: An ongoing challenge in precision medicine is the efficient delivery of therapeutics to tissues/organs of interest. Nanoparticle delivery systems have the potential to overcome traditional limitations of drug and gene delivery through improved pharmacokinetics, tissue targeting, and stability of encapsulated cargo. Physalis mottle virus (PhMV)-like nanoparticles are a promising nanocarrier platform which can be chemically targeted on the exterior and interior surfaces through reactive amino acids. Cargo-loading to the internal cavity is achieved with thiol-reactive small molecules. However, the internal loading capacity of these nanoparticles is limited by the presence of a single reactive cysteine (C75) per coat protein with low inherent reactivity. Here, we use structure-based design to

SUBMITTER: Barkovich KJ 

PROVIDER: S-EPMC10538386 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature